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The noticed not enough an important accumulation of PHN in brain adhering to the intraventricular administration of (+)-amphetamine and the formation of appreciable amounts of PHN from (+)-POH in brain tissue in vivo supports the see that the aromatic hydroxylation of amphetamine subsequent its systemic administration occurs predominantly while in the periphery, and that POH is more info then transported with the blood-brain barrier, taken up by noradrenergic neurones in Mind where (+)-POH is transformed while in the storage vesicles by dopamine β-hydroxylase to PHN. ^
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corepressor – a protein (or a little molecule) that actually works with transcription aspects to decrease the rate of gene transcription